Acronyms are commonly used when talking about gastro-esophageal reflux disease. Here are a few you need to know:

Acronym Translation Details



American College of Gastroenterology The ACG provides its members with the most accurate and up-to-date scientific information on digestive health and the etiology, symptomatology and treatment of GI disorders.



American Gastroenterological Association Organization of physicians, researchers and educators whose primary practice or research involves the functions and disorders of the digestive system. It has grown to include more than 16,000 members from around the globe who are involved in all aspects of the science, practice and advancement of gastroenterology



Anti-Reflux Barrier Composed of well-defined structuresthat work synergistically to keep stomach contents out of the esophagus (even when you are upside down). The components of the ARB are: a) GEV, b) LES, c) crura of the diaphragm, which “pinch” the distal esophagus aiding in closing the esophagus, d) intra-abdominal length of the esophagus which is exposed to positive intra-abdominal pressure, e) esophageal peristalsis / motility and clearance, f) abdomino-thoracic pressure difference.



American Society of Gastrointestinal Endoscopy The ASGS seeks to serve as a knowledgeable and respected advocate for General Surgeon specialists, and also seeks to enhance General Surgery as a specialty.
BMI Body Mass Index A simple and widely used method for estimating body fat. In epidemiology BMI alone is used as an indicator of prevalence and incidence.

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DDW Digestive Disease Week The largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT). The meeting showcases more than 5,000 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology.
DMS DeMeester Score Uses parameters such as total reflux and number of episodes to numerically measure esophageal acidity and assess the severity of gastroesophageal reflux disease (GERD). It is most commonly used to document the severity of GERD, with a score >14.72 representing reflux considered significant.
EAE esophageal acid exposure EAE, if abnormal, is used to objectively document GERD. Abnormal EAE is often determined by either 48-h wireless pH BRAVO or 24-h ambulatory pH testing while off PPI therapy for at least seven days. If determined by the 24-h test, the normal value is usually considered to be <4.5% (% total time pH <4). If determined by 48-h pH BRAVO, the normal value is ≤ 5.3% (% total time pH < 4).
EAC esophageal adenocarcinoma High grade dysplasia in the esophagus a serious complication of Barrett’s and has been the most rapidly rising form of cancer in the United States since the mid-1970’s.
ECAN Esophageal Cancer Action Network Its mission is to save lives by increasing awareness about the link between Heartburn and Cancer, promoting early detection and supporting medical innovation to prevent, detect and treat Esophageal Cancer.
EGD Esophago-gastroduodenoscopy Involves insertion of an endoscope through the mouth and throat into the esophagus and stomach (often while the patient is sedated) in order to assess the internal surfaces of the esophagus, stomach, and duodenum.
EGJ Esophagogastric Junction (also called cardia) Anatomical term for the junction orifice of the stomach and the esophagus. At this level, the mucosa of the esophagus transitions into gastric mucosa.
ELF Endo Luminal Fundoplication The first technical description and preliminary version of the TIF procedure
ENT Ear, Nose Throat A type of surgeon in the field of otolaryngology, the study of diseases in the ear canals and upper airway. Some atypical GERD symptoms that ENTs sometimes see first are hoarseness, throat clearing, cough, sore throat, dysphagia, or globus.
FLIP Functional Lumen Imaging Probe Created by McMahon et al to measure cross-sectional sectional areas of the esophagus at extremely small intervals.
GEJ Gastroesophageal Junction see EGJ
GERD Gastroesophageal Reflux Disease A chronic condition in which acid from the stomach flows back into the lower esophagus, causing pain or tissue damage; also known as acid reflux.
GSRS Gastrointestinal Symptom Rating Scale Scale used to diagnose the severity of gastrointestinal symptoms and to determine treatment for patients suffering from such symptoms. The GSRS contains five scales: reflux syndrome, abdominal pain, constipation syndrome, diarrhea syndrome and indigestion syndrome.
GERSS Gastroesophageal Reflux Symptom Score Assess heartburn, regurgitation, bloating, and dysphagia and epigastric/retrosternal pain (Anvari 2006). The total scale ranges from 0 to 60 where a “well-controlled” score is defined as < 18.
GEV Gastroesophageal Valve The 3 – 4 cm musculo-mucosal fold created through the oblique Angle of His at which the esophagus enters the stomach. This flap valve opens only for swallowing and closes promptly. When competent and fully intact, prevents the reflux of gastric contents up into the esophagus.
GI Gastroenterologist


a type of physician practicing in the field of gastroenterology, the study of the digestive system and digestive diseases
H2 blocker

also called H2RA

Histamine type-2 receptor antagonist (stomach acid) Drugs that prevent or block the production of gastric acid. A pump in the stomach releases hydrochloric acid when stimulated by histamine. H2 blockers prevent histamine from stimulating this pump, thereby reducing the amount of acid that is released into the stomach. H2 blockers are available over-the-counter (OTC) or by prescription [e.g. Cimetidine (Tagamet), Famotidine (Pepcid), Ranitidine (Zantac)].
HH Hiatal Hernia Protrusion (or herniation) of the upper part of the stomach into the thorax through a tear or weakness in the diaphragm.
HPZ High Pressure Zone Detected manometrically—is the lower end of the esophagus does not have a true anatomic sphincter.
HRM High Resolution Manometry Gastrointestinal motility diagnostic system that measures intraluminal pressure activity in the gastrointestinal tract using a series of closely spaced pressure sensors.
HRQL Health Related Quality of Life Validated survey to quantify the subjectivity of patient symptoms to identify GERD.
LA Grade Los Angeles Grade scale used to classify severity of esophagitis (inflammation of the esophagus)
LES Lower Esophageal Sphincter A ring of smooth muscle fibers at the junction of the esophagus and stomach; also called cardiac sphincter, gastroesophageal sphincter.
LF Laparoscopic Fundoplication Procedure that involves wrapping the fundus 360° around the surgically mobilized distal esophagus using a less invasive approach.
LERD Laryngopharyngeal Esophageal Reflux Disease Proximal gastroesophageal reflux affecting the upper esophagus and airway with concomitant ENT symptoms or signs such as hoarseness, throat clearing, cough, sore throat, dysphagia, or globus.
LPR Laryngopharyngeal Reflux Proximal see LERD
MII Multi-Channel Intraluminal Impedance High resolution manometry—may be combined with manometry or pH studies to examine patient symptoms to a higher degree of specificity. MII-pH augments current esophageal pH monitoring by detecting non-acid reflux and weakly acidic reflux (pH exposure ≥ 4) in patients with atypical symptoms or in patients who continue to experience typical symptoms despite use of medical therapy.
NERD Non-Erosive Reflux Disease One of many types of GERD characterized as reflux disease without esophagitis, i.e. without the slow erosion of the lining of the esophagus.
pH A 0-14 scale measuring acidity (0) to neutral (7) to alkalinity (14) and for GERD patients, used in determining the level of stomach acidity and percentage of time the esophagus is exposed to stomach acid.
pH-metry pH manometry see MMI
PPI Proton Pump Inhibitors Drugs that reduce the production of acid by blocking the enzyme in the wall of the stomach that produces acid. The reduction of acid prevents ulcers and allows any ulcers that exist in the esophagus, stomach and duodenum to heal. Examples: Omeprazole (Prilosec), Iansoprazole (Prevacid), Esomeprazole (Nexium).
RDQ Reflux Disease Questionnaire Validated survey to quantify the subjectivity of patient atypical symptoms to identify GERD.
RESPECT Randomized EsophyX vs. Sham / Placebo Controlled TIF Trial As defined by the Montreal consensus definition while on PPIs compared with sham and placebo controls.: The objective of the study is to evaluate the relative merits, safety and effectiveness of the EsophyX transoral device in performing an advanced TIF procedure in patients with “troublesome symptoms”
RFS Reflux Finding Score Validated survey to quantify the subjectivity of patient symptoms to identify GERD.
RSI Reflux Symptom Index Validated survey to quantify the subjectivity of patient atypical symptoms to identify GERD.
SAGES Society of American Gastrointestinal and Endoscopic Surgeons Organization represents a worldwide community of surgeons that can bring minimal access surgery, endoscopy and emerging techniques to patients in every country. Representing over 6,500 surgeons and allied health professionals.
TEMPO TIF® versus Medical PPI Management of Refractory GERD symptoms trial First level one data for the TIF procedure, abstract presented at DDW 2013.
TIF Transoral Incisionless Fundoplication Minimally invasive (no cutting) procedure that reconstructs the GEV from inside the stomach by forming a ~270 degree wrap using the EsophyX® device under direct visualization by an endoscope.
UES Upper Esophageal Sphincter Natural resistance area located in cervical esophagus consisting of cricopharyngeus and inferior pharyngeal constrictor muscles.
UGI Upper Gastrointestinal series A radiologic examination of the upper gastrointestinal tract.
Z-line Zigzag line The squamocolumnar junction where the lining changes from white esophageal (squamous) tissue to red gastric (columnar) tissue. The line is irregular hence the name Z (zigzag) line. The lower esophageal sphincter is located in this area. (Ok not an acronym but cool info just the same.)